Emergence of SARS-CoV-2 Spike Mutations during Prolonged Infection in Immunocompromised Hosts
Karrie Kwan Ki Ko, Hatairat Yingtaweesittikul, Thuan Tong Tan, Limin Wijaya, Delphine Yanhong Cao, Sui Sin Goh, Nurdyana Binte Abdul Rahman, Kenneth X. L. Chan, Hui Ming Tay, James Heng Chiak Sim, Kian Sing Chan, Lynette Lin Ean Oon, Niranjan Nagarajan, Chayaporn Suphavilai
Abstract
The emergence of clinically important mutations described in this report highlights the need for sustained vigilance and containment measures when managing immunocompromised patients with persistent COVID-19. Even as jurisdictions across the globe start lifting pandemic control measures, immunocompromised patients with persistent COVID-19 constitute a unique group that requires close genomic monitoring and enhanced infection control measures, to ensure early detection and containment of mutations and variants of therapeutic and public health importance.