Systemic delivery of mRNA and DNA to the lung using polymer-lipid nanoparticles
James C. Kaczmarek, Asha K. Patel, Luke H. Rhym, Umberto Capasso Palmiero, Balkrishen Bhat, Michael W. Heartlein, Frank DeRosa, Daniel G. Anderson
Topics & Concepts
Nucleic acidTransfectionMessenger RNAEndosomeCytosolIn vivoDNABiophysicsGene deliveryMolecular biologyIntracellularMaterials scienceBiochemistryBiologyCell biologyGeneEnzymeBiotechnologyRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesVirus-based gene therapy research