Prosaposin mediates inflammation in atherosclerosis
Mandy M. T. van Leent, Thijs J. Beldman, Yohana C. Toner, Marnix Lameijer, Nils Rother, Siroon Bekkering, Abraham J. P. Teunissen, Xianxiao Zhou, Roy van der Meel, Joost Malkus, Sheqouia A. Nauta, Emma D. Klein, François Fay, Brenda L. Sánchez-Gaytán, Carlos Pérez‐Medina, Ewelina Kluza, Yuxiang Ye, Gregory R. Wojtkiewicz, Edward A. Fisher, Filip K. Świrski, Matthias Nahrendorf, Bin Zhang, Yang Li, Bowen Zhang, Leo A. B. Joosten, Gerard Pasterkamp, Arjan Boltjes, Zahi A. Fayad, Esther Lutgens, Mihai G. Netea, Niels P. Riksen, Willem J. M. Mulder, Raphaël Duivenvoorden
Abstract
expression and inflammation in human carotid atherosclerotic plaques. Our findings provide mechanistic insights into the development of atherosclerosis and identify prosaposin as a potential therapeutic target.