Highly Efficient Electrocarboxylation Method to Synthesize Novel Acid Derivatives of 1,4-Dihydropyridines and to Study Their Antimicrobial Activity
Dharambeer Singh Malhi, Harvinder Singh Sohal, Kishanpal Singh, Zainab M. Almarhoon, Abir Ben Bacha, Maha I. Al‐Zaben
Abstract
were found to be highly active at 4 μg/mL with reference to standard amoxicillin and fluconazole. Further, the present synthetic protocol would open new gates for other researchers to develop new molecules by bioisosteres of these substrates.
Topics & Concepts
ChemistryAntimicrobialDHPSMoietyPyrazineCombinatorial chemistryStereochemistryOrganic chemistryBiologyPlasmodium falciparumMalariaImmunologyMulticomponent Synthesis of HeterocyclesPhenothiazines and Benzothiazines Synthesis and ActivitiesSynthesis and Biological Evaluation