A sulfonyl fluoride derivative inhibits EGFRL858R/T790M/C797S by covalent modification of the catalytic lysine
Francesca Ferlenghi, Laura Scalvini, Federica Vacondio, Riccardo Castelli, Nicole Bozza, Giuseppe Marseglia, Silvia Rivara, Alessio Lodola, Silvia La Monica, Roberta Minari, Pier Giorgio Petronini, Roberta Alfieri, Marcello Tiseo, Marco Mor
Topics & Concepts
ChemistryOsimertinibT790MSulfonylKinomeLead compoundDHPSStereochemistryBiochemistryKinaseIn vitroErlotinibEpidermal growth factor receptorReceptorPlasmodium falciparumAlkylGefitinibImmunologyMalariaBiologyOrganic chemistryLung Cancer Treatments and MutationsCancer therapeutics and mechanismsBiochemical and Molecular Research