First-time imaging of [89Zr]trastuzumab in breast cancer using a long axial field-of-view PET/CT scanner
Adrienne H. Brouwers, Joyce van Sluis, Johannes H. van Snick, Carolina P. Schröder, Inge O. Baas, Ronald Boellaard, Andor W.J.M. Glaudemans, Ronald Borra, Adriaan A. Lammertsma, Rudi Dierckx, Charalampos Tsoumpas
Abstract
Long axial field-of-view (LAFOV) PET/CT scanners have been introduced recently [1, 2], which offer numerous advantages One important advantage of using LAFOV PET/CT for imaging 89 Zr-labelled monoclonal antibodies (mAbs), i.e., immunoPET, is the substantial increase in sensitivity compared with standard axial field-of-view (SAFOV) PET/CT systems, which may lead to a remarkable image quality improvement. This first study showcases such improvement for immunoPET with Biograph Vision Quadra (VQ) LAFOV PET/CT (Siemens Healthineers, Knoxville, TN, USA).