Insulin-like growth factor 2 mRNA-binding protein 2-stabilized long non-coding RNA Taurine up-regulated gene 1 (TUG1) promotes cisplatin-resistance of colorectal cancer via modulating autophagy
Cuifeng Xia, Qiang Li, Xianshuo Cheng, Tao Wu, Pin Gao, Yongfang Gu
Abstract
experiments in nude mice probed the function and mechanism of IGF2BP2 in CRC cell growth. The profiles of TUG1 and IGF2BP2 were elevated in CRC tissues, and IGF2BP2 enhanced TUG1's expression in CRC cells. TUG1 activated autophagy to facilitate CRC cells' resistance to DDP. TUG1 targets miR-195-5p, and miR-195-5p targets HDGF. Overexpression of miR-195-5p abated the cancer-promoting function of TUG1 and curbed the profile of the HDGF/DDX5/β-catenin axis. TUG1 stabilized by IGF2BP2 boosted CRC cell proliferation, migration, migration, and autophagy via the miR-195-5p/HDGF/DDX5/β-catenin axis, hence enhancing CRC cell's resistance to DDP.
Topics & Concepts
Messenger RNAGeneAutophagyCancer researchChemistryColorectal cancerCisplatinInsulin resistanceInsulin-like growth factorTaurineCell biologyGrowth factorBiologyEndocrinologyInternal medicineInsulinCancerMedicineBiochemistryApoptosisAmino acidChemotherapyReceptorCancer-related molecular mechanisms researchRNA modifications and cancerMicroRNA in disease regulation