Mechanistic insights on age-related changes in heart-aorta-brain hemodynamic coupling using a pulse wave model of the entire circulatory system
Arian Aghilinejad, Faisal Amlani, Sohrab P. Mazandarani, Kevin S. King, Niema M. Pahlevan
Abstract
We investigated the impact of major aging mechanisms of the arterial system and cardiac function on brain hemodynamics. Our findings suggest that aging has a significant impact on heart-aorta-brain coupling through changes in both arterial stiffening and left ventricle (LV) contractility. Understanding the underlying physical mechanisms involved here can potentially be a key step for developing more effective therapeutic strategies that can mitigate the contributions of abnormal LV-arterial coupling toward neurodegenerative diseases and dementia.
Topics & Concepts
HemodynamicsContractilityCirculatory systemVentricleCardiologyMedicineInternal medicineAortaCardiovascular Health and Disease PreventionHeart Rate Variability and Autonomic ControlOptical Imaging and Spectroscopy Techniques