Biological relevance of Granzymes A and K during <i>E. coli</i> sepsis
Iratxe Uranga-Murillo, Elena Tapia, Marcela Garzón-Tituaña, Ariel Ramírez-Labrada, Llipsy Santiago, Cecilia Pesini, Patricia Esteban, Francisco J. Roig, Eva M. Gálvez, Phillip I. Bird, Julián Pardo, Maykel Arias
Abstract
-induced sepsis, inhibition of GzmA is sufficient to reduce inflammation and improve survival irrespectively of the presence of other inflammatory granzymes, like GzmK.
Topics & Concepts
Granzyme AGranzymeProinflammatory cytokineSepsisExtracellularProteasesImmunologyInflammationTLR4BiologyChemistryGranzyme BCell biologyImmune systemPerforinT cellEnzymeBiochemistryCD8Cell death mechanisms and regulationS100 Proteins and AnnexinsNatural Compounds in Disease Treatment