Auxiliary Proteins are the Predominant Determinants of Differential Efficacy of Clinical Candidates Acting as AMPA Receptor Positive Allosteric Modulators
Toshiyuki Ishii, Jacob R. Stolz, Geoffrey T. Swanson
Topics & Concepts
AMPA receptorAllosteric regulationReceptorDifferential (mechanical device)Allosteric modulatorComputational biologyChemistryPharmacologyBiologyCell biologyBiochemistryGlutamate receptorPhysicsThermodynamicsNeuroscience and Neuropharmacology ResearchIon channel regulation and functionBiochemical effects in animals