New-onset lupus nephritis associated with COVID-19 infection
Brigitte Kazzi, Derek M. Fine, Duvuru Geetha, Melody P. Chung, Manny Monroy-Trujillo, Homa Timlin
Abstract
A dysregulated immune response plays a critical role in systemic lupus erythematosus (SLE) pathogenesis. Environmental factors such as viruses, including coronavirus 2 (COVID-19), have been described to play a role in SLE presentation and exacerbation. These viruses trigger a host's humoral and cellular immunities typically essential in elimination of the viral infection. We present a case of a Hispanic male who developed new-onset lupus nephritis class II after a COVID-19 infection.
Topics & Concepts
Lupus nephritisMedicineImmunologyExacerbationPathogenesisCoronavirus disease 2019 (COVID-19)Immune systemSystemic lupus erythematosusNephritisVirologyDiseasePathologyInfectious disease (medical specialty)Systemic Lupus Erythematosus ResearchSARS-CoV-2 and COVID-19 ResearchDiabetes and associated disorders