Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years
Christine Durier, Läétitia Ninove, M. Lefèbvre, Anne Radenne, Corinne Desaint, Jacques Ropers, Rebecca Bauer, Saïd Lebbah, Diane Carette, Marie Lachâtre, Anne-Sophie Lecompte, Dominique Deplanque, Élisabeth Botelho-Nevers, Anne Conrad, Bertrand Dussol, Z. Maakaroun-Vermesse, Giovanna Melica, Jean‐François Nicolas, Renaud Verdon, Jacques Kiladjian, Paul Loubet, Catherine Schmidt‐Mutter, Christian Dualé, Séverine Ansart, Stéphane Priet, Axel Levier, Diana Molino, Louis-Victorien Vieillard, Béatrice Parfait, Jean‐Daniel Lelièvre, Éric Tartour, Xavier de Lamballerie, Odile Launay, ANRS0002S CoviCompareP Group, Study sites, Gilbert Mchantaf, Berthe‐Marie Imbert‐Marcille, Samantha Montagne, Bijan Ghaleh-Marzban, Alexandra Traverse‐Glehen, Denis Vivien, Bruno Cassinat, Alexandre Evrard, Catherine Metzger, Jean‐Marc Lessinger, Michel Billing, Marc Berger, Christophe Leroyer, Laboratories, Éric Tartour, Victor Appay, Frédéric Batteux, Béhazine Combadière, Guy Gorochov, Stéphane Paul, Sylvie Van Der Werf, Christiane S. Eberhardt, Claire‐Anne Siegrist, Michel Cogné, Isabelle Pellegrin, Marc Éloit, Trial coordination, Emmanuelle Netzer, Martine Resch, Marine Saouzanet, Laurence Meyer, Marion Bonneton, Sponsor, Raphaëlle Tardieu, Soizic Le Mestre, Solange Jancrey-Laval, Ventzislava Petrov–Sanchez, Éric Rosenthal, Yazdan Yazdanpanah, Daniel Olive, Raphaëlle Tardieu, Ventzislava Petrov-Sanchez, Amel Bouakane, Véronique Rieux, Claire Madelaine, Soizic Lemestre, Alpha Diallo, Solange Lancrey-javal, Laurence Meyer, Emmanuelle Netzer, Marine Saouzanet, AP-HP CoviCompareM Group, Study sites, Florent Valour, Bertrand Dussol, Giovanna Melica, Gilbert Mchantaf, Michael Hisbergues, Frédérique Bertholon, Vinca Icard, Annachiara De Sandre‐Giovannoli, Bijan Ghaleh-Marzban, Laboratories, Victor Appay, Frédéric Batteux
Abstract
Immune response induced by COVID-19 vaccine booster against delta and omicron variants was assessed in 65 adults (65-84 years old) early aftesr a first booster dose. An increase in SARS-CoV-2 neutralizing antibodies was shown in individuals not previously infected without evidence of an age-related effect, with lower increase in those infected before a single dose of primary vaccination. Of note, humoral response was observed only starting from the 5th day after the boost.