Structural characterization of a monomethylauristatin-E based ADC that contains 8 drugs conjugated at interchain cysteine residues

David Chiu, Lucy Pan, Lindsay Fay, Catherine M. Eakin, John Valliere‐Douglass

2021Journal of Pharmaceutical and Biomedical Analysis10 citationsDOI

Topics & Concepts

ChemistryConjugated systemLinkerConjugateCysteineBiophysicsCombinatorial chemistryStereochemistryBiochemistryOrganic chemistryEnzymeMathematical analysisComputer scienceMathematicsOperating systemBiologyPolymerMonoclonal and Polyclonal Antibodies ResearchHER2/EGFR in Cancer ResearchCell Adhesion Molecules Research