The Effect of <i>Rusa unicolor</i> Antler Deer Extracts from East Kalimantan in Bone Turnover Cell Models
Retno WIDYOWATI, Suciati SUCIATI, Dewi Melani Haryadi, Hsin‐I Chang, IPG Ngurah Suryawan, Agung Widi UTAMA
Abstract
OBJECTIVES: antler's horn from East Kalimantan on nitric oxide inhibition, osteoblast differentiation, and mineralization related to bone turnover. MATERIALS AND METHODS: -nitrophenyl phosphate. Their effects on mineralization was determined using alizarin red staining. RESULTS: The 70% ethanol and aqueous extracts inhibited cell inflammation (40% and 80%, respectively) and stimulated osteoblast differentiation (65% and 52%, respectively). In the mineralization test, the aqueous extract showed an effect two times higher than that of 70% ethanol extract. CONCLUSION: The extracts can effectively degrade inflammatory marker expression and preserve osteoblast functions.