Solid‐State Direct Electrophilic Selenocyanation of (Hetero)Arenes using Mechanochemistry
Jun‐An Xiao, Jin‐Shao Liang, Huan Zhang, Ru‐Fang Meng, Wei‐Fang Su, Chenxiang Lin, Jianguo Cui, Yanmin Huang
Abstract
Abstract A mechanochemical direct selenocyanation of arenes/heterocyclic arenes with electrophilic selenocyanating reagents to access (hetero)aryl selenocyanates has been developed. This protocol provided an efficient strategy to access various aromatic selenocyanates in yields up to 99 % under ball‐milling reaction conditions within 60 minutes. Gram‐scale reaction and further transformations of the product were conducted to demonstrate the synthetic utilities of this method.
Topics & Concepts
ChemistryMechanochemistryElectrophileReagentArylBall millCombinatorial chemistryOrganic chemistryCatalysisChemical engineeringAlkylEngineeringOrganoselenium and organotellurium chemistrySulfur-Based Synthesis TechniquesVanadium and Halogenation Chemistry