Assessing the Perturbing Effects of Drugs on Lipid Bilayers Using Gramicidin Channel-Based <i>In Silico</i> and <i>In Vitro</i> Assays
Delin Sun, Thasin Peyear, William F. Bennett, Matthew Holcomb, Stewart He, Fangqiang Zhu, Felice C. Lightstone, Olaf S. Andersen, Helgi I. Ingólfsson
Abstract
approaches, which allow for predicting the perturbing effects of drug candidates on membrane protein function, have implications for preclinical drug safety assessment.
Topics & Concepts
GramicidinChemistryLipid bilayerIn silicoBilayerBiophysicsPhosphocholineMembraneDrugIn vitroBiochemistryPhospholipidPharmacologyPhosphatidylcholineBiologyGeneLipid Membrane Structure and BehaviorForce Microscopy Techniques and ApplicationsRNA Interference and Gene Delivery