Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling
Uddalak Majumdar, Sathiyanarayanan Manivannan, Madhumita Basu, Yukie Ueyama, Mark C. Blaser, Emily Cameron, Michael R. McDermott, Joy Lincoln, Susan E. Cole, Stephen A. Wood, Elena Aïkawa, Brenda Lilly, Vidu Garg
Abstract
in mice demonstrated CAVD and human calcified aortic valves displayed reduced S-nitrosylation of USP9X. These results demonstrate a previously unidentified mechanism by which S-nitrosylation-dependent regulation of a ubiquitin-associated pathway prevents CAVD.
Topics & Concepts
Nitric oxideS-NitrosylationCalcificationNotch signaling pathwayCell biologyAortic valveChemistrySignal transductionMedicineCardiologyInternal medicineBiologyBiochemistryCysteineEnzymeCardiac Valve Diseases and TreatmentsAortic Disease and Treatment ApproachesNitric Oxide and Endothelin Effects