<i>In</i> <i>Silico</i> Classifiers for the Assessment of Drug Proarrhythmicity
Jordi Llopis‐Lorente, Julio Gomis-Tena, Jordi Cano, Lucía Romero, Javier Sáiz, Beatriz Trénor
Abstract
tool can be useful for the preclinical assessment of TdP-risk and to reduce costs related with new drug development. The TdP risk-assessment tool and the software used in this work are available at https://riunet.upv.es/handle/10251/136919.
Topics & Concepts
hERGDrugIn silicoTorsades de pointesFalse positive paradoxQT intervalBiomarkerMedicinePharmacologyMachine learningComputer scienceInternal medicineChemistryPotassium channelBiochemistryGeneCardiac electrophysiology and arrhythmiasIon channel regulation and functionAnalytical Methods in Pharmaceuticals