Rational design and combinatorial chemistry of ionizable lipids for RNA delivery
Yue Xu, Alex Golubovic, Shufen Xu, Anni Pan, Bowen Li
Abstract
, cholesterol, helper lipid, and PEGylated lipid, are almost identical. Therefore, ionizable lipids are critical to the delivery efficiency of mRNA. This review covers recent advances in ionizable lipids used in RNA delivery over the past several decades. We will discuss chemical structures, synthetic routes, and structure-activity relationships of ionizable lipids.
Topics & Concepts
Rational designRNAChemistryNanoparticleNanotechnologyCombinatorial chemistryBiochemistryMaterials scienceGeneRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesLipid Membrane Structure and Behavior