Factors governing tumor penetration of nanomedicines: intrinsic and extrinsic determinants
Dongwon Shin, Jiwoong Choi, Byeongmin Park, Sun Hwa Kim, Man Kyu Shim
Abstract
This review provides a comprehensive understanding of the multifactorial determinants influencing tumor penetration of nanoparticles, highlighting how a systems-level understanding of these interdependent factors can accelerate rational design.
Topics & Concepts
NanoparticleNanotechnologyPenetration (warfare)NanomedicineInterdependenceMaterials scienceComputer scienceDrug deliverySystemic circulationBiochemical engineeringMass transportCancer treatmentPredictabilityRisk analysis (engineering)Nanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryAdvanced Drug Delivery Systems