The stiffness-dependent tumor cell internalization of liquid metal nanoparticles
Jing He, Wen Pang, Bobo Gu, Xubo Lin, Jian Ye
Abstract
tailoring the surface oxidation and silica coating. It has been found that the softer NPs would be endocytosed much slower than their stiffer counterparts in the presence of specific ligand-receptor interaction. Interestingly, once the interaction is eliminated, softer NPs are internalized faster than the stiffer ones. Based on experimental observations and theoretical verification, we demonstrate that this phenomenon is mainly caused by varying degrees of deformation of soft NPs induced by ligand-receptor interactions. Such a finding of the stiffness effect of NPs implies great potential for fundamental biomedical applications, such as the rational design of nanomedicines.
Topics & Concepts
InternalizationMaterials scienceNanoparticleNanomedicineStiffnessNanotechnologyRational designLigand (biochemistry)Eutectic systemBiophysicsCoatingMetalIndiumEndocytosisReceptorChemistryComposite materialAlloyMetallurgyBiochemistryBiologyGold and Silver Nanoparticles Synthesis and ApplicationsNanoparticle-Based Drug DeliveryNanopore and Nanochannel Transport Studies