Prevalence and Determinants of Fatigue in Patients with IBD: A Cross-Sectional Survey from the GETAID
Aurélien Amiot, Sayma Chaibi, Yoram Bouhnik, Mélanie Serrero, Jérôme Filippi, Xavier Roblin, Anne Bourrier, Guillaume Bouguen, Denis Franchimont, Guillaume Savoye, Anthony Buisson, Édouard Louis, Stéphane Nancey, Véred Abitbol, Jean‐Marie Reimund, Olivier Dewit, Lucine Vuitton, Nicolas Mathieu, Laurent Peyrin‐Biroulet, Cyrielle Gilletta, Matthieu Allez, Stéphanie Viennot, Catherine Le Berre, Nina Dib, Hédia Brixi, Claire Painchart, Laurianne Plastaras, Romain Altwegg, Mathurin Fuméry, Ludovic Caillo, David Laharie, Maria Nachury, GETAID-patient experience study group, Aurélien Amiot, Sara Tadbiri, Charlotte Gagnière, Jenny Tannoury, Maria Nachury, Benjamin Pariente, Pauline Wils, Yoram Bouhnik, Carmen Stefănescu, Xavier Tréton, Carole Martins, Mathieu Uzzan, Melanie Serrero, Jérôme Filippi, Xavier Hébuterne, Nadia Arab, Virginie Cluzeau, Xavier Roblin, Émilie Del Tedesco, Laurent Beaugerie, Philippe Seksik, Anne Bourrier, Cecilia Landmann, Julien Kirchgesner, Harry Sokol, Guillaume Bouguen, Laurent Siproudhis, Marie Dewitte, Denis Franchimont, Guillaume Savoye, Anthony Buisson, Édouard Louis, Cathérine Reenaers, Stéphane Nancey, Gilles Boschetti, Claire Gay, Pauline Danion, Bernard Flourié, Vered Abitbol, Georgia Malamut, Jean‐Marie Reimund, Bénédicte Caron, Olivier DeWitt, Lucine Vuitton, Nicolas Mathieu, Sandie Pestour, Thomas Chateau, Laurent Peyrin‐Biroulet, Camille Zallot, Cyrielle Gilletta, Matthieu Allez, Jean-Marc Gornet, Clotilde Baudry, Stéphanie Viennot, Arnaud Bourreille, Caroline Trang-Poisson, Nina Dib, Hedi Brixi, Guillaume Cadiot, Médina Boualit, Claire Painchart, Laurianne Plastaras, Romain Altwegg, Lucile Boivineau, Mathurin Fuméry, Ludovic Caillo, David Laharie
Abstract
BACKGROUND: Fatigue is commonly reported by patients with inflammatory bowel disease [IBD], but the determinants of IBD-related fatigue have yet to be determined. AIMS: To identify the factors associated with fatigue in a large population of patients with IBD. PATIENTS AND METHODS: Fatigue and nine other IBD-related disability dimensions were assessed in a cohort of 1704 consecutive patients with IBD using the IBD-disk questionnaire in a cross-sectional survey of 42 French and Belgian centres. Fatigue and severe fatigue were defined as energy subscores >5 and >7, respectively. Determinants of fatigue were assessed using univariate and multivariate analyses (odds ratios [ORs] are provided with 95% confidence intervals). RESULTS: The prevalence rates of fatigue and severe fatigue were 54.1% and 37.1%, respectively. Both fatigue and severe fatigue were significantly higher in patients with active disease than in patients with inactive disease [64.9% vs 44.7% and 47.4% vs 28.6%, respectively; p < 0.001 for both comparisons]. In the multivariate analysis stratified by age, sex, type of IBD and IBD activity, fatigue was associated with age >40 years (OR = 0.71 [0.54-0.93]), female sex (OR = 1.48 [1.13-1.93]) and IBD-related sick leave (OR = 1.61 [1.19-2.16]), and joint pain (OR = 1.60 [1.17-2.18]), abdominal pain (OR = 1.78 [1.29-2.45]), regulating defecation (OR = 1.67 [1.20-2.32]), education and work (OR = 1.96 [1.40-2.75]), body image (OR = 1.38 [1.02-1.86]), sleep (OR = 3.60 [2.66-4.88]) and emotions (OR = 3.60 [2.66-4.88]) subscores >5. CONCLUSION: Determinants of fatigue are not restricted to IBD-related factors but also include social factors, sleep and emotional disturbances, thus supporting a holistic approach to IBD patient care.