Green Approach for Visible-Light-Induced Direct Functionalization of 2-Methylquinolines
Juliana A. Dantas, Radell Echemendía, Marília S. Santos, Márcio W. Paixão, Marco A. B. Ferreira, Arlene G. Corrêa
Abstract
A transition metal- and oxidant-free visible light-photoinduced protocol for direct functionalization of 2-methylquinolines has been developed. This protocol enabled the C-H functionalization of substituted 2-methylquinolines with diacetyl or ethyl pyruvate, under environmentally friendly conditions. A mechanistic investigation based on density functional theory (DFT) calculations provided details about the origins of reactivity and selectivity.
Topics & Concepts
ChemistrySurface modificationVisible spectrumCombinatorial chemistryPhotochemistryOptoelectronicsPhysical chemistryPhysicsRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques