The Muscle Carnosine Response to Beta-Alanine Supplementation: A Systematic Review With Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis
Nathália Saffioti Rezende, Paul Swinton, Luana Farias de Oliveira, Rafael Pires da Silva, Vinicius da Eira Silva, Kleiner Nemezio, Guilherme Yamaguchi, Guilherme Giannini Artioli, Bruno Gualano, Bryan Saunders, Eimear Dolan
Abstract
= 99). The Emax model indicated that human skeletal muscle has large capacity for non-linear MCarn accumulation, and that commonly used BA supplementation protocols may not come close to saturating muscle carnosine content. Neither baseline values, nor sex, appeared to influence subsequent response to supplementation. Analysis of individual data indicated that MCarn is relatively stable in the absence of intervention, and effectually all participants respond to BA supplementation (99.3% response [95%CrI: 96.2-100]).
Topics & Concepts
Meta-analysisCarnosineBayesian probabilityBETA (programming language)Bayesian inferenceMedicineBioinformaticsEconometricsComputational biologyInternal medicineComputer scienceStatisticsMathematicsBiologyProgramming languageBiochemical effects in animalsFree Radicals and Antioxidants