Hybrid Thermophilic/Mesophilic Enzymes Reveal a Role for Conformational Disorder in Regulation of Bacterial Enzyme I
Rochelle R. Dotas, Trang Nguyen, Charles Stewart, Rodolfo Ghirlando, Davit A. Potoyan, Vincenzo Venditti
Topics & Concepts
ThermophileMesophileEnzymeProtein engineeringBiochemistryChemistryActive siteProtein structureDirected evolutionBiologyBacteriaMutantGeneticsGeneProtein Structure and DynamicsEnzyme Structure and FunctionRNA and protein synthesis mechanisms