Dearomative [4 + 2] annulations between 3-nitroindoles and enals through oxidative N-heterocyclic carbene catalysis
Hua Huang, Qing‐Zhu Li, Yanqing Liu, Hai‐Jun Leng, Peng Xiang, Qing‐Song Dai, Xiang‐Hong He, Wei Huang, Jun‐Long Li
Abstract
A novel intermolecular dearomative [4 + 2] annulation of 3-nitroindoles and enals under oxidative N-heterocyclic carbene catalysis has been developed. This protocol was also suitable for the oxidative cyclisation of 2-nitrobenzothiophenes with enals.
Topics & Concepts
ChemistryCarbeneOxidative phosphorylationAnnulationCatalysisIntermolecular forceOrganocatalysisCombinatorial chemistryOrganic chemistryBiochemistryMoleculeEnantioselective synthesisN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions