EDA complex-mediated [3 + 2] cyclization for the synthesis of CF<sub>3</sub>-oxadiazoles
Mengjun Huang, Guoqiang Wang, Heyin Li, Zhenlei Zou, Xingye Jia, G. Karotsis, Yi Pan, Weigang Zhang, Jing Ma, Yi Wang
Abstract
A catalyst-free method to synthesize 1,3,4-oxadiazoles via EDA complex of α-diazo sulfonium triflates and dihydropyridines, featuring mild conditions, high functional group tolerance, and broad applicability for late-stage drug derivatization.
Topics & Concepts
ChemistryCombinatorial chemistryStereochemistryCyclopropane Reaction MechanismsFluorine in Organic Chemistry