Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance
Fumihiko Nakao, Kiyoko Setoguchi, Yuichiro Semba, Takuji Yamauchi, Jumpei Nogami, Kensuke Sasaki, Hiroshi Imanaga, Tatsuya Terasaki, Manaka Miyazaki, Shigeki Hirabayashi, Kohta Miyawaki, Yoshikane Kikushige, Takeshi Masuda, Koichi Akashi, Takahiro Maeda
Topics & Concepts
MCL1VenetoclaxCRISPRUbiquitin ligaseApoptosisBiologyVenCancer researchCell biologyDNA ligaseLeukemiaMolecular biologyUbiquitinGeneticsDownregulation and upregulationDNAChronic lymphocytic leukemiaGeneComputer securityComputer scienceAcute Myeloid Leukemia ResearchAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery