Tertiary amines as a C1 synthon: metal-free synthesis of quinolines and 2-substituted quinolines<i>via</i>[3+2+1] aerobic cyclization and C–N bond cleavage
Jingyuan Liu, Zhenying Wang, Qiang Li, Dacheng Li, Jian-Min Dou
Abstract
An I 2 -mediated aerobic cyclization reaction of anilines, alkynes, and tertiary amine has been reported. In this protocol, a novel strategy for the synthesis of quinolines using tertiary amines as a C1 synthon via C–N bond cleavage.
Topics & Concepts
SynthonChemistryCleavage (geology)Bond cleavageAmine gas treatingMedicinal chemistryTertiary amineCombinatorial chemistryStereochemistryOrganic chemistryCatalysisFracture (geology)Geotechnical engineeringEngineeringCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsCatalytic Cross-Coupling Reactions