Unseen toxins: Exploring the human health consequences of micro and nanoplastics
John G. Dennis, Divya Arulraj, Tapan Kumar Mistri
Abstract
Micro and nanoplastics (MNPs) contamination constitute a pressing global issue with considerable ramifications for human health. Particles originating from the decomposition of plastic waste permeate ecosystems and disturb biological systems, especially the gastrointestinal (GI) tract. MNPs compromise the intestinal barrier, provoke oxidative stress, inflammation, and immunological dysfunction, and modify gut microbiota, which is associated with metabolic problems, inflammatory bowel disease (IBD), and colorectal cancer. MNPs traverse biological barriers beyond the gastrointestinal system, including the blood-brain barrier, colonic mucus layer, and placental barrier, resulting in accumulation in essential organs such as the liver, kidneys, and brain. This results in inflammatory damage, metabolic abnormalities, and oxidative stress, specifically affecting liver disease due to microbiota metabolite alteration and nephrotoxicity in the kidneys. Airborne MNPs pose an additional risk to respiratory health, aggravating ailments such as asthma, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis. At-risk groups, such as pregnant women, newborns, and the elderly, encounter increased dangers, as MNPs traverse the placental barrier and may induce neurological and intergenerational health consequences. These particles function as vectors for environmental pollutants, exacerbating their cardiovascular and neurological effects. Addressing the long-term consequences of MNP exposure necessitates interdisciplinary collaboration to enhance comprehension and alleviate their growing risk to human health. • Micro and nanoplastics circulate through the bloodstream and build up in the body. • Oxidative stress, protein dysregulation, and lysosomal damage are key pathways. • Long term MNP exposure possesses the carcinogenicity potential. • Disruptions on the gut-brain axis led to neurogenic disorders. • Smaller MNPs pose a greater health risk by more easily infiltrating tissues and cells.