Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F
Guanghui Zong, Zhijian Hu, Kwabena B. Duah, Lauren Andrews, Jianhong Zhou, Sarah O’Keefe, Lucas Whisenhunt, Joong Sup Shim, Yuchun Du, Stephen High, Wei Shi
Abstract
enabled gram-scale production, allowing us to establish that ipomoeassin F is biologically active in vivo (MTD: ∼3 mg/kg).
Topics & Concepts
ChemistryRing (chemistry)IC50In vivoStereochemistryGene isoformCytotoxicityIn vitroCombinatorial chemistryBiochemistryOrganic chemistryGeneBiologyBiotechnologyCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins ResearchChemical Synthesis and Analysis