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Development of anti-breast cancer PI3K inhibitors based on 7-azaindole derivatives through scaffold hopping: Design, synthesis and in vitro biological evaluation

Chengbin Yang, Mingzhu Lu, Yi Chen, Ruiqing Xiang, Tianze Qiu, Jia Yu, Yongtai Yang, Xiaofeng Liu, Mingli Deng, Yun Ling, Yaming Zhou

2021Bioorganic Chemistry19 citationsDOI

Topics & Concepts

PI3K/AKT/mTOR pathwayChemistryBreast cancerIn vitroCancerKinaseProtein kinase BCell growthApoptosisIntracellularCancer cellCancer researchPharmacologyBiochemistryBiologyInternal medicineMedicinePI3K/AKT/mTOR signaling in cancerSynthesis and biological activityProtein Degradation and Inhibitors
Development of anti-breast cancer PI3K inhibitors based on 7-azaindole derivatives through scaffold hopping: Design, synthesis and in vitro biological evaluation | Litcius