Investigating the reactive oxygen species production of Rose Bengal and Merocyanine 540-loaded radioluminescent nanoparticles
Anne Nsubuga, Gabrielle A. Mandl, John A. Capobianco
Abstract
assays along with electron paramagnetic resonance were employed to determine that superoxide and hydroxyl radicals were exclusively produced from this system under X-ray excitation. Knowledge of the correct PDT mechanism is crucial for informing what types of disease may be best suited for treatment using PDT nanosystems.
Topics & Concepts
Singlet oxygenRose bengalReactive oxygen speciesPhotodynamic therapyPhotochemistryChemistryRadicalSuperoxideOxygenElectron paramagnetic resonanceNanoparticlePhotosensitizerNanomaterialsHydroxyl radicalNanotechnologyMaterials scienceNuclear magnetic resonanceOrganic chemistryBiochemistryEnzymePhysicsNanoplatforms for cancer theranosticsLuminescence Properties of Advanced MaterialsPhotodynamic Therapy Research Studies