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Development of teixobactin analogues containing hydrophobic, non-proteogenic amino acids that are highly potent against multidrug-resistant bacteria and biofilms

Anish Parmar, Rajamani Lakshminarayanan, Abhishek Iyer, Eunice Tze Leng Goh, Tsz Ying To, Joey Kuok Hoong Yam, Liang Yang, Enas Newire, Maria C. Robertson, Stephen H. Prior, Eefjan Breukink, Annemieke Madder, Ishwar Singh

2023European Journal of Medicinal Chemistry16 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryStaphylococcus aureusBiofilmAmino acidBacteriaResidue (chemistry)Lipid IIBiochemistryAntibacterial activityMultiple drug resistanceMicrobiologyStereochemistryAntibioticsBiosynthesisBiologyEnzymeGeneticsAntimicrobial Peptides and ActivitiesProbiotics and Fermented FoodsAntimicrobial Resistance in Staphylococcus
Development of teixobactin analogues containing hydrophobic, non-proteogenic amino acids that are highly potent against multidrug-resistant bacteria and biofilms | Litcius