Boron-ellagic acid hybrids as a molecular arrow: multi-targeted inhibition of AChE, anticancer activity, and antimicrobial action against MRSA and MDR E. coli, supported by docking analyses
Metin Yıldırım, Eyyup Yasar, Adem Necip, Mehmet Çimentepe, Gökhan Öztürk, Ahmet Kılıç
Topics & Concepts
Ellagic acidChemistryAntimicrobialDocking (animal)Lead compoundProtein Data Bank (RCSB PDB)AntioxidantEnzymeBiological activityStereochemistryMechanism of actionBiochemistryCombinatorial chemistryIn vitroAntibacterial activityStructure–activity relationshipCytotoxicityCell cultureResidue (chemistry)Cancer cell linesIC50Cancer cellActive siteAlkaloidMolecular modelPharmacologyTriazoleReceptorPomegranate: compositions and health benefitsChemotherapy-induced cardiotoxicity and mitigationFerrocene Chemistry and Applications