Recent Progress in Enolonium Chemistry under Metal‐Free Conditions
Ravi Kumar, Quynh H. Nguyen, Tae‐Woong Um, Seunghoon Shin
Abstract
Umpolung approach through inversion of the polarity of conventional enolates, has opened up an unprecedented opportunity in the cross-coupling via alkylation. The enolonium equivalents can be accessed either by hypervalent iodine reagents, activation/oxidation of amides, or the oxidation of alkynes. Under umpolung conditions, highly basic conditions required for classical enolate chemistry can be avoided, and they can couple with unmodified nucleophiles such as heteroatom donors and electron-rich arenes.
Topics & Concepts
UmpolungHypervalent moleculeNucleophileChemistryReagentHeteroatomAlkylationCombinatorial chemistryOrganic chemistryComputational chemistryCatalysisAlkylOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization MethodsAdvanced Synthetic Organic Chemistry