Species-Wide Phylogenomics of the Staphylococcus aureus <i>Agr</i> Operon Revealed Convergent Evolution of Frameshift Mutations
Vishnu Raghuram, Ashley M. Alexander, Hui Qi Loo, Robert A. Petit, Joanna B. Goldberg, Timothy D. Read
Abstract
Staphylococcus aureus is a globally pervasive pathogen that produces a plethora of toxic molecules that can harm host immune cells. Production of these toxins is mainly controlled by an active agr quorum-sensing system, which senses and responds to bacterial cell density.
Topics & Concepts
PhylogenomicsOperonFrameshift mutationStaphylococcus aureusBiologyGeneticsConvergent evolutionEvolutionary biologyPhylogeneticsMutationGeneBacteriaEscherichia coliCladeGenomics and Phylogenetic StudiesMicrobial Natural Products and BiosynthesisAntimicrobial Resistance in Staphylococcus