α-Tubulin acetylation on lysine 40 controls cardiac glucose uptake
Edith Renguet, Marine De Loof, Natacha Fourny, Audrey Ginion, Caroline Bouzin, Christian Poüs, Sandrine Horman, Christophe Beauloye, Laurent Bultot, Luc Bertrand
Abstract
Acetylation level of α-tubulin on K40 is increased in the heart of a diet-induced mouse model of type 2 diabetes. Pharmacological stimulation of α-tubulin K40 acetylation lowers insulin-mediated GLUT4 vesicles translocation to the plasma membrane, reducing glucose transport. Expressing a nonacetylable dominant form of α-tubulin boosts glucose uptake in both insulin-sensitive and insulin-resistant cardiomyocytes.
Topics & Concepts
AcetylationGLUT4Glucose transporterTubulinBiologyGlucose uptakeInsulinBiochemistryMicrotubuleCell biologyEndocrinologyGeneMetabolism, Diabetes, and CancerProtein Tyrosine PhosphatasesAutophagy in Disease and Therapy