Polyphenols as NLRP3 inflammasome modulators in cardiometabolic diseases: a review of<i>in vivo</i>studies
Marisol Villalva, Juan José Martínez-García, Laura Jaime, Susana Santoyo, Pablo Pelegrı́n, Jara Pérez‐Jiménez
Abstract
studies. A clear tendency towards a decrease in the expression of the whole NLRP3 inflammasome signaling pathway when several animal models were supplemented with polyphenols was observed, commonly showing a dose-response effect; these modifications were concomitant with clinical improvements in the pathologies. Nevertheless, the diversity of doses used, the disparity in polyphenol structures tested and, particularly, the scarce clinical trials and exploration of mechanisms of action show the need to develop further research on the topic.
Topics & Concepts
InflammasomeIn vivoPolyphenolChemistryPharmacologyTraditional medicineMedicineBiochemistryBiologyBiotechnologyAntioxidantReceptorInflammasome and immune disordersCholesterol and Lipid MetabolismDiet, Metabolism, and Disease