Synthesis of strained 1,2-diazetidines via [3 + 1] cycloaddition of C,N-cyclic azomethine imines with isocyanides and synthetic derivation

Wenbin Cao, Shuai Jiang, Haiyan Li, Xiaoping Xu, Shun‐Jun Ji

2021Organic Chemistry Frontiers16 citationsDOI

Abstract

Strained diazetidines are assembled simply from 1,3-dipolar cycloaddition of isocyanides and <italic>C,N</italic>-cyclic azomethine imines, and their diversified transformations are presented.

Topics & Concepts

CycloadditionChemistryAzomethine ylide1,3-Dipolar cycloadditionMedicinal chemistryCombinatorial chemistryComputational chemistryStereochemistryOrganic chemistryCatalysisSynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsSynthesis of β-Lactam Compounds

Synthesis of strained 1,2-diazetidines <i>via</i> [3 + 1] cycloaddition of <i>C</i>,<i>N</i>-cyclic azomethine imines with isocyanides and synthetic derivation

Abstract

Topics & Concepts