Synthesis of Highly Fused Pyrano[2,3-<i>b</i>]pyridines via Rh(III)-Catalyzed C–H Activation and Intramolecular Cascade Annulation under Room Temperature
Xu Han, Feng Gao, Chunpu Li, Daqing Fang, Xiong Xie, Yu Zhou, Hong Liu
Abstract
]pyridines has been established under room temperature via Rh(III)-catalyzed C-H bond activation and intramolecular cascade annulation. This strategy features high efficiency, unique versatility, and generality and it can occur under mild conditions in good to excellent yields. More importantly, this strategy can be extended to the late-stage functionalization of drugs possessing the CN group.
Topics & Concepts
AnnulationChemistryIntramolecular forceCatalysisCascadeCombinatorial chemistryCascade reactionSurface modificationStereochemistryMedicinal chemistryOrganic chemistryPhysical chemistryChromatographyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCyclopropane Reaction Mechanisms