Early Neonatal Meconium Does Not Have a Demonstrable Microbiota Determined through Use of Robust Negative Controls with <i>cpn</i> 60-Based Microbiome Profiling
Scott J Dos Santos, Zahra Pakzad, Chelsea Elwood, Arianne Albert, Soren Gantt, Amee R. Manges, Tim Dumonceaux, Evelyn J. Maan, Janet E. Hill, Deborah Money, The Maternal Microbiome Legacy Project Team
Abstract
Much like the recent placental microbiome controversy, studies of neonatal meconium reporting bacterial communities within the fetal and neonatal gut imply that microbial colonization begins prior to birth. However, recent work has shown that placental microbiomes almost exclusively represent contamination from lab reagents and the environment.
Topics & Concepts
MeconiumMicrobiomeBiologyMicrobiologyColonizationPulsed-field gel electrophoresisIn uteroPhysiologyImmunologyFetusGeneticsPregnancyGeneGenotypeGut microbiota and healthReproductive tract infections researchUrinary Tract Infections Management