Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation
Patrick Flagmeier, Suman De, Thomas C. T. Michaels, Xiaoting Yang, Alexander J. Dear, Cecilia Emanuelsson, Michele Vendruscolo, Sara Linse, David Klenerman, Tuomas P. J. Knowles, Christopher M. Dobson
Topics & Concepts
BiophysicsKineticsProtein aggregationChemistryAmyloid (mycology)Lipid bilayerNucleationVesicleFluorescence microscopeFibrilMembraneOligomerFluorescenceCell biologyBiochemistryBiologyQuantum mechanicsInorganic chemistryPhysicsOrganic chemistryAlzheimer's disease research and treatmentsPrion Diseases and Protein MisfoldingProtein Structure and Dynamics