Cleaner and greener synthesis of 3<i>H</i>-benzothiazole-2-thione and its derivatives
Nitin Srivastava, Ram Kishore
Abstract
A cleaner and greener method of synthesis of 3H-benzothiazole-2-thione is being reported in this communication. In this method, various o-iodoaniline derivatives are reacted with carbon disulfide in the presence of Cs2CO3 and tetramethyl ammonium bromide (TMAB) to give 3H-benzothiazole-2-thione and its derivatives in higher yields.
Topics & Concepts
BenzothiazoleChemistryCarbon disulfideAmmonium bromideBromideAmmoniumOrganic chemistryDisulfide bondSulfurMedicinal chemistryCombinatorial chemistryPulmonary surfactantBiochemistrySynthesis and Reactivity of Sulfur-Containing CompoundsSynthesis and biological activitySulfur-Based Synthesis Techniques