Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors
Zilun Hu, Cailan Wang, Doree Sitkoff, Nathan L. Cheadle, Songmei Xu, J.K. Muckelbauer, Leonard P. Adam, Ruth R. Wexler, Mimi L. Quan
Topics & Concepts
ChemistryPyridineROCK2KinomeSelectivityROCK1PyrimidineStereochemistryKinaseIC50Combinatorial chemistryMedicinal chemistryBiochemistryProtein kinase AIn vitroRho-associated protein kinaseCatalysisProtein Kinase Regulation and GTPase SignalingCancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer