CAR T Cell Therapy for Chronic Lymphocytic Leukemia: Successes and Shortcomings
Željko Todorović, Dusan Todorovic, Vladimir Marković, Nevena Ladjevac, Nataša Zdravković, Predrag Djurdjević, Nebojša Arsenijević, Marija Milovanović, Aleksandar Arsenijević, Jelena Milovanović
Abstract
Chimeric antigen receptor T (CAR T) cell therapy achieved remarkable success in B-cell leukemia and lymphoma which led to its incorporation in treatment protocols for these diseases. CAR T cell therapy for chronic lymphocytic leukemia (CLL) patients showed less success compared to other malignant tumors. In this review, we discuss the published results regarding CAR T cell therapy of CLL, possible mechanisms of failures and expected developments.
Topics & Concepts
Chimeric antigen receptorChronic lymphocytic leukemiaMedicineCAR T-cell therapyLeukemiaLymphomaCancer researchT cellCell therapyImmunologyCellImmune systemBiologyGeneticsCAR-T cell therapy researchVirus-based gene therapy research