Increased islet antigen–specific regulatory and effector CD4 <sup>+</sup> T cells in healthy individuals with the type 1 diabetes–protective haplotype
Xiaomin Wen, Junbao Yang, Eddie A. James, I‐Ting Chow, Helena Reijonen, William W. Kwok
Abstract
The DR1501-DQ6 haplotype confers protection against type 1 diabetes through islet-specific T regs and IL-10–producing T effs .
Topics & Concepts
EffectorIsletType 1 diabetesBiologyAntigenImmunologyHaplotypeType 2 diabetesDiabetes mellitusCell biologyGeneGeneticsEndocrinologyGenotypeDiabetes and associated disordersPancreatic function and diabetesImmune Cell Function and Interaction