27-Hydroxycholesterol is a specific factor in the neoplastic microenvironment of HCC that causes MDR via GRP75 regulation of the redox balance and metabolic reprogramming
Ming Jin, Ye Yang, Yi Dai, Rong Cai, Liunan Wu, Yuwen Jiao, Zhan Zhang, Haojun Yang, Yan Zhou, Liming Tang, Lei Li, Yuan Li
Topics & Concepts
Cancer researchTumor microenvironmentChemistryReactive oxygen speciesProtein kinase BTumor promotionCytotoxicityBiologyCell biologySignal transductionCarcinogenesisBiochemistryIn vitroGeneTumor cellsCholesterol and Lipid MetabolismCancer, Lipids, and MetabolismHormonal Regulation and Hypertension