Apelin Prevents and Alleviates Crystalline Silica-induced Pulmonary Fibrosis via Inhibiting Transforming Growth Factor Beta 1-triggered Fibroblast Activation
Jianling Shen, Jiayin Feng, Zhijia Wu, Yushi Ou, Qing Zhang, Qiying Nong, Qifeng Wu, Cong Li, Xiaohui Tan, Meng Ye, Zhongxiang Gao, Ying Zhang, Weihui Liang, Lihua Xia, Yiru Qin, Yongshun Huang, Na Zhao, Shijie Hu
Abstract
data demonstrated that pre-treatment from day 3 and post-treatment from day 15 with apelin could both alleviate silica-induced pulmonary fibrosis in mice. Besides, apelin inhibited pulmonary fibroblast activation via transforming growth factor beta 1 (TGF-β1) signaling. Our study suggested that apelin could prevent and reverse silica-induced pulmonary fibrosis by inhibiting the fibroblast activation through TGF-β1 signaling pathway, thus providing a new potential therapeutic strategy for silicosis and other pulmonary fibrosis.
Topics & Concepts
SilicosisApelinPulmonary fibrosisFibrosisTransforming growth factorFibroblastMedicineLungTransforming growth factor betaReceptorPharmacologyInternal medicineCancer researchImmunologyPathologyBiologyIn vitroBiochemistryApelin-related biomedical researchCardiovascular, Neuropeptides, and Oxidative Stress ResearchMacrophage Migration Inhibitory Factor