Tentonin 3/TMEM150C regulates glucose-stimulated insulin secretion in pancreatic β-cells
Jungwon Wee, Sungmin Pak, Tahnbee Kim, Gyu‐Sang Hong, Ji Seon Lee, Jinyan Nan, Hyungsup Kim, Mi‐Ock Lee, Kyong Soo Park, Uhtaek Oh
Abstract
mice show impaired glucose tolerance with decreased insulin secretion in vivo. We propose that TTN3, as a stretch-activated cation channel, contributes to glucose-stimulated insulin secretion.
Topics & Concepts
InsulinInternal medicineEndocrinologyDepolarizationSecretionGlucose homeostasisHomeostasisBiologyPancreatic isletsMembrane potentialCarbohydrate metabolismChemistryIsletInsulin resistanceBiophysicsMedicineIon channel regulation and functionPancreatic function and diabetesIon Transport and Channel Regulation